SOFA Score Calculator

What is the SOFA Score?

The Sequential Organ Failure Assessment (SOFA) score is a validated clinical grading system used in intensive care units (ICU) to determine the extent of a patient's organ function or failure rate. The score grades dysfunction across six distinct vital organ systems: respiratory, hematologic (coagulation), hepatic (liver), cardiovascular, central nervous system, and renal.

Regularly calculating the SOFA score allows healthcare teams to monitor disease progression, evaluate therapeutic response, and assess overall mortality risk in critically ill patients, especially those with sepsis. For bedside screening outside the ICU, check our qSOFA Score Calculator.

The 6 Organ Systems in SOFA Scoring

Each of the six systems is scored on an integer scale from 0 (normal physiology) to 4 (severe organ failure), resulting in a total score between 0 and 24:

• Respiration: Evaluated using the \( \text{PaO}_2 / \text{FiO}_2 \) ratio in mmHg or kPa, incorporating mechanical ventilation support requirements.
• Coagulation: Measured by platelet count (\(\times 10^3/\mu\text{L}\)).
• Liver: Assessed through serum bilirubin levels (\(\text{mg/dL}\) or \(\mu\text{mol/L}\)).
• Cardiovascular: Graded by Mean Arterial Pressure (MAP) and the dosing of inotropes/vasopressors (dopamine, dobutamine, epinephrine, norepinephrine).
• Central Nervous System: Measured using the Glasgow Coma Scale (GCS) score.
• Renal: Evaluated using serum creatinine levels or 24-hour urine output volume.

SOFA Score and ICU Mortality Correlation

According to foundational multicenter clinical studies, cumulative SOFA scores correlate strongly with in-hospital ICU mortality:

• 0 to 1 points: 0.0% to 3.3% mortality
• 2 to 3 points: 3.4% to 7.1% mortality
• 4 to 5 points: 7.2% to 12.5% mortality
• 6 to 7 points: 12.6% to 21.5% mortality
• 8 to 9 points: 21.6% to 33.3% mortality
• 10 to 11 points: 33.4% to 50.0% mortality
• 12 to 14 points: 50.1% to 80.0% mortality
• 15 to 24 points: Over 80.0% to 95.0%+ mortality