Light's Criteria Calculator
Classify pleural fluid as transudate or exudate using Light's criteria from protein and LDH lab values.
What Are Light's Criteria?
Light's criteria help distinguish exudative from transudative pleural effusions using pleural fluid and serum laboratory values. An exudate suggests local pleural disease such as infection, malignancy, or inflammation, while a transudate points to systemic causes like heart failure or cirrhosis. For related pulmonary assessment, see the Dead Space Calculator and BODE Index Calculator.
How Light's Criteria Work
Three ratios are calculated from a pleural fluid sample paired with serum labs. If any one criterion is met, the effusion is classified as an exudate. Criterion 1: pleural protein divided by serum protein is at least 0.5. Criterion 2: pleural LDH divided by serum LDH is at least 0.6. Criterion 3: pleural LDH divided by the upper limit of normal serum LDH is at least 0.67.
Transudate vs Exudate
Transudates occur when hydrostatic or oncotic pressure shifts move fluid into the pleural space without significant pleural inflammation. Common causes include congestive heart failure, nephrotic syndrome, and hepatic hydrothorax. Exudates reflect active pleural injury or capillary leak and warrant further workup such as cytology, culture, or imaging based on clinical context.
Frequently Asked Questions
When is a pleural effusion classified as an exudate?
Any single Light's criterion met defines an exudate. You do not need all three ratios to exceed their thresholds.
What labs are needed for Light's criteria?
You need pleural fluid protein and LDH plus matching serum protein, serum LDH, and the laboratory upper normal limit for serum LDH.
What causes a transudative pleural effusion?
Common transudative causes include congestive heart failure, cirrhosis with ascites, and nephrotic syndrome. These reflect systemic fluid balance rather than pleural inflammation.
Can Light's criteria misclassify an effusion?
Occasionally. Diuretic therapy can concentrate transudates and mimic exudates. Borderline results may need additional tests such as pleural fluid cholesterol or albumin gradient.
What is the protein ratio threshold?
Pleural fluid protein divided by serum protein must be at least 0.5 to satisfy the first Light criterion for exudate.
What LDH ratio thresholds apply?
Pleural LDH divided by serum LDH must be at least 0.6, or pleural LDH divided by the upper normal serum LDH must be at least 0.67. Either LDH criterion alone is sufficient for exudate classification.