Lille Score Calculator

What Is the Lille Score?

The Lille model score predicts response to corticosteroid therapy in patients with severe alcoholic hepatitis. It is calculated on day 7 of steroid treatment using admission laboratory values plus the change in bilirubin. A score below 0.45 identifies responders who benefit from continuing steroids; scores of 0.45 or higher suggest non-response and worse 6-month survival. For related liver severity scoring, see the MELD Calculator.

How the Lille Model Is Calculated

First compute the intermediate R value: R = 3.19 − (0.101 × age) + (0.147 × albumin in g/L) + (0.0165 × [bilirubin day 7 − bilirubin day 0 in μmol/L]) − (0.206 × renal insufficiency) − (0.0065 × bilirubin day 0 in μmol/L) − (0.0096 × PT in seconds). Renal insufficiency equals 1 when creatinine exceeds 1.3 mg/dL (115 μmol/L), otherwise 0. The Lille score is then exp(−R) / (1 + exp(−R)).

Interpreting Results

A Lille score below 0.45 indicates a likely steroid responder — continue corticosteroid therapy with close monitoring. A score of 0.45 or higher indicates a non-responder; guidelines often recommend stopping steroids and considering alternative management. Always interpret alongside clinical status, infection, bleeding risk, and other prognostic scores.