Benzodiazepine Conversion Calculator
Convert benzodiazepine doses using alprazolam-equivalent factors across common anxiolytics.
Convert Between Benzodiazepine Doses
Benzodiazepine conversion tables express each drug relative to alprazolam (Xanax). To switch agents, divide the current dose by the source drug factor, then multiply by the target drug factor. This calculator performs that conversion and displays a full equivalency table for common agents including diazepam, lorazepam, clonazepam, and midazolam.
Conversion Formula
$$\text{target dose (mg)} = \frac{\text{source dose (mg)}}{\text{source factor}} \times \text{target factor}$$
Important Clinical Notes
Equivalent doses are approximations. Half-life, onset, potency at receptors, and patient factors differ between agents. Cross-tapering under medical supervision is safer than abrupt switches. IV midazolam and oral midazolam use different factors because absorption and use cases differ.
Frequently Asked Questions
What is the reference drug for this chart?
Alprazolam is the reference with a factor of 1. Every other benzodiazepine is expressed as a multiple of that equivalent.
How do I convert diazepam to alprazolam?
Divide the diazepam dose by 15, then multiply by 1. For example, 15 mg diazepam converts to about 1 mg alprazolam equivalent.
Why are IV and oral midazolam different?
Route changes bioavailability and clinical context. This table uses factor 4 for IV midazolam and factor 10 for oral midazolam.
Can I use this to stop benzodiazepines?
No. Taper plans require individualized schedules. This tool only estimates dose equivalence, not discontinuation protocols.
Are brand and generic names interchangeable here?
Yes for dose conversion purposes when the active benzodiazepine is the same. Always confirm the exact product and route with the prescriber.